Manchester United midfielder Michael Carrick has joined long-term absentees Paul Pogba, Marcos Rojo and Zlatan Ibrahimovic on the sidelines.
Phil Jones, Antonio Valencia, Marouane Fellaini and Anthony Martial will all be assessed.
Crystal Palace striker Christian Benteke is out for at least six weeks because of knee ligament damage.
Ruben Loftus-Cheek is injured, James Tomkins is ill and Timothy Fosu-Mensah is ineligible to face his parent club.
Freddie Ladapo, 24, is Palace’s only fit striker and could make his competitive debut for the club.
Watch Live Stream below: –